Fig. 4.

Analyses of public databases on human ACCs suggest a role for glutathione peroxidases and ferroptosis. (A) Gene expression and DNA methylation of epigenetically silenced genes in human ACCs, according to Zheng et al. in ref. 5. (B) Selected differentially expressed genes in normal adrenocortical tissue, adrenocortical adenomas and ACCs indicate a role for ferroptosis sensitivity in ACCs. (C) Cystathionase (CTH cystathionine gamma-lyase) catalyzed reaction and generation of cysteine, initially identified in ref. 4. (D) Five µM of MIA602 are sufficient to kill more than 50% of H295R cells in cell culture.