Fig. 1.

SKN-1 activation causes redistribution of somatic lipids and activation of immune defense genes. (A) Normal lipid distribution in wild-type animals (representative image from n = 873) as compared to (B) somatic depletion of fat (Asdf) in animals with activated SKN-1 (representative image from n = 759) that occurs with age (C). (D) GO-term enrichment analysis of differentially expressed genes from RNA-seq of day 2 adult skn-1gf mutant animals as compared to age-matched WT controls. Analysis of the mRNA reads of the indicated genes related to (E) innate immunity and pathogen resistance and (F) oxidative stress and xenobiotic responses; see Dataset S1 for all RNA-seq measurements. (G) Venn diagram of gene expression changes with at least 2-fold change in skn-1gf(lax188) mutants during development (L4 stage) and day 2 of adulthood. See also Datasets S1 and S4 for all RNA-seq measurements. (Scale bar, 50 μm.) ****P < 0.0001. FPKM, fragments per kilobase of transcript per million mapped reads.