Table 1.

Shared increased autoantibodies/autoantigens between hypophysitis patients 1, 2, and 3 in response to ipilimumab

Gene name and description	Molecular functions and associated diseases
GNAL, G-protein alpha-activating activity polypeptide olfactory type	Mediates odorant signaling in olfactory epithelium; associated with dystonia 25
ITM2B	Associated with ganglion cell abnormalities, cerebral amyloid angiopathy, and familial British and Danish dementia
MIIP	Suppresses tumors by inhibiting cell migration and invasion
PTGDS	Involved in variety of central nervous system functions such as sedation, non–rapid-eye-movement sleep, and prostaglandin 2-induced allodynia
APH1A gamma secretase	Catalyzes the cleavage of Notch receptor and beta-amyloid precursor protein, associated with Alzheimer’s disease
ERMN (ERM-like protein)	Plays a role in late-stage oligodendroglia maturation, myelin/Ranvier node formation