Fig. 1.

Generation of Eµ-Myc;p53ER^TAM lymphomas with active p53. (A) Scheme illustrating the experimental outline. HSC, hematopoietic stem cells from fetal liver. (B) Volcano plot depicting fold change in gene expression (log₂FC) and significance (−log₁₀P) for Eµ-Myc;p53^+/+ and Eµ-Myc;p53^−/− lymphomas (n = 4 each). (C) ARF mRNA expression of lymphomas with indicated p53 genotype and activity status. Expression of individual lymphomas is shown normalized to β-actin as ΔCt (mean ± SD, 1-way ANOVA with Tukey’s multiple comparisons test). (D) Immunostaining of ARF and p53 (CM5) for lymphomas with indicated p53 genotype and activity status.