Fig. 5.

Increased chaperone capacity extends life span. (A) Chaperone dependence of relative (rel.) life span ($\tau /{\tau }_o$, where ${\tau }_o$ is the life span with wild-type [WT] chaperone level) at T = 20 ^○C (blue line), T = 25 ^○C (orange line), and $T=30{}^{○}\text{C}$ (red line). The predicted increase of life span (orange line) quantitatively captures the experimentally observed life span extension at $T=25{}^{○}\text{C}$ (black triangles) (77). (B) The temperature dependence of life-span extension due to a 2-fold increase in chaperone level with (solid line) and without (dashed line) the ability of chaperones to bind, and thus be titrated by, damaged protein.