Fig. 1.

Baseline lncRNA expression predicts drug sensitivity in cancer cell lines. Thousands of cancer cell lines have been tested for cell viability in response to the addition of hundreds of compounds. The same cell lines have been extensively characterized, including the measurement of transcriptome-wide RNA levels. Using the expression of lncRNAs as predictor variables in regularized linear regression models, individual lncRNAs that are strongly predictive of sensitivity to a drug across cancer cell lines can be uncovered. Thus, these drug–lncRNA relationships have potential to be used as biomarkers to inform patient care.