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Specificity constants for the hydrolysis of natural substrates under physiological conditions
| Enzyme | Fibrinogen kcat/Km (mM−1 s−1) |
PAR1 kcat/Km (mM−1 s−1) |
Protein C1 kcat/Km (mM−1 s−1) |
|---|---|---|---|
| MZ4R | 540 ± 48 | 5000 ± 210 | 65 ± 0.3 |
| MZ4R (+PL)2 | 400 ± 28 | 3700 ± 150 | 2400 ± 51 |
| MZ4R/WE | 0.23 ± 0.01 | 7 ± 0.3 | 0.45 ± 0.002 |
| MZ4R/WE (+PL)2 | 0.44 ± 0.04 | 11 ± 0.3 | 72 ± 1 |
| Thrombin3 | 17000 ± 1000 | 32000 ± 2000 | 220 ± 10 |
| WE Thrombin3 | 0.25 ± 0.02 | 10 ± 1 | 33 ± 2 |
