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. 2019 Nov 1;38:446. doi: 10.1186/s13046-019-1458-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — OMP-52M51 significantly impedes DLL4-induced upregulation of numerous genes involved in lymphoid biology, lymphomagenesis and disease progression mimicking the signature of NOTCH mutated MCL lymph nodes. Heatmaps displaying the significantly upregulated genes and grouped by pathway signaling obtained after GSEA analysis (Custom MCL set of genes) of (a) Mino cells treated with OMP-52M51 after DLL4-stimulation and (b) MCL lymph nodes with or without mutation in NOTCH genes. c Volcano plot filtering of 55 genes differentially expressed in NOTCH-mutated MCL lymph nodes. d Enrichment of biological processes found by PANTHER gene ontology analysis of the volcano-filtered genes differentially expressed in NOTCH-mutated MCL lymph nodes