Table 1.
Selectivity of compound 1 for AAK1 against the NAK family kinases
| Binding Displacement Assay | |||
|---|---|---|---|
| NAK | IC50 (μM) | Ki (μM) | Ki / Ki (AAK1) |
| AAK1 | 1.17 | 0.541 | 1.0 |
| BMP2K | 10.1 | 4.40 | 8.13 |
| GAK | 3.25 | 1.75 | 3.23 |
| STK16 | 20.0 | 11.9 | 22.0 |
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