. Author manuscript; available in PMC: 2020 Jun 27.

Published in final edited form as: J Med Chem. 2019 Jun 12;62(12):5810–5831. doi: 10.1021/acs.jmedchem.9b00136

Table 7.

Selectivity scores (S scores) for compound 21b at 10 μM

S-score type	Number of Hits	Number of Non-Mutant Kinases	Selectivity Score
S(35)^a	212	403	0.526
S(10)^b	138	403	0.342
S(1)^c	49	403	0.122

S(35) = (number of non-mutant kinases with %Ctrl <35)/(number of non-mutant kinases tested)

S(10) = (number of non-mutant kinases with %Ctrl <10)/(number of non-mutant kinases tested)

S(1) = (number of non-mutant kinases with %Ctrl <1)/(number of non-mutant kinases tested)