Skip to main content
. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Cancer Res. 2019 Jul 16;79(21):5482–5489. doi: 10.1158/0008-5472.CAN-19-1302

Figure 4. Depletion of CD8+ T cells abrogates the antitumor effects of ACY1215 and anti-PD-L1 combination.

Figure 4.

(A) ARID1Aflox/flox/PIK3CAH1047R OCCCs were induced by intrabursal adenovirus-encoded Cre injection and allowed to establish for four weeks. The mice were randomized into three indicated experimental groups (n=5 mice/group). The depletion of CD8+ T cells was confirmed by flow cytometry analysis of blood cells collected via the retro-orbital vein. (B) Images of dissected reproductive tracks with tumors were shown in the right panel. The weights of the dissected tumors were quantified as a surrogate for tumor burden in the middle panel, and ascites produced were quantified in the right panel. (C) After three weeks treatment, the mice were followed for survival and shown are the Kaplan–Meier survival curves. (D) At the end of treatment, percentage of CD69 positive CD4 T cells was assessed by flow cytometry in the dissected tumors. Error bars represent ± S.E.M.