Table 2:
Number of patients (highest grade/patient) with possibly, probably, or definitively grade 2,3 or 4 vandetanib related toxicities.
| Toxicity Grade CTCAEv4 | 2 | 3 | 4 |
|---|---|---|---|
| Gastrointestinal Toxicity | |||
| nausea | 1 | ||
| diarrhea | 1 | 1 | |
| oral mucositis | 1 | ||
| stomach pain | 1 | ||
| Hepatic Toxicity | |||
| alkaline phosphatase ↑ | 2 | ||
| AST ↑ | 1 | ||
| ALT ↑ | 1 | ||
| Metabolic/Laboratory Toxicity | |||
| calcium ↓ | 1 | ||
| glucose ↑ | 1 | ||
| Constitutional Toxicity | |||
| fatigue | 1 | ||
| anorexia | 2 | ||
| Hematologic Toxicity | |||
| Lymphocyte Count ↓ | 1 | 1 | |
| Skin Toxicity | |||
| rash acneiform | 2 | ||
| pruritis | 1 | ||
| Neurologic Toxicity | |||
| headache | 1 | ||
| seizure | 1 | ||
| Genitourinary Toxicity | |||
| proteinuria | 2 | ||
| Vascular disorders | |||
| hypertension | 4 | 2 | |
| Pulmonary | |||
| pneumonitis | 1 | ||
| dyspnea | 1 | ||
| hypoxia | 1 |