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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Mol Cancer Res. 2019 Aug 28;17(11):2221–2232. doi: 10.1158/1541-7786.MCR-19-0408

Figure 1.

Figure 1.

Induction of IL-24 by NR4A1 antagonist. (A) Rh30 cells were treated with CDIM8 in the absence (-) or presence of IL-24 knockdown (siIL-24) and whole cell lysates were analyzed by western blots. (B) Rh30 cells were treated with 20 uM CDIM8 for different times or for 24 hours (C) and whole cell lysates were analyzed by western blots. (D) ARMS cells were transfected with pCMV-IL24 expression plasmid and after 24 hour whole cell lysates were analyzed by western blots. (E) Tumor lysates from athymic nude mice bearing Rh30 cells as xenografts (39) and treated with corn oil (control) or adenoviral – IL-24 were analyzed by western blots. Results are expressed as means ± SD for at three replicate determinations for each treatment group (E) and significant (p<0.05) effects (*) are indicated.