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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Mol Cancer Res. 2019 Aug 28;17(11):2221–2232. doi: 10.1158/1541-7786.MCR-19-0408

Figure 7.

Figure 7.

IL-24 – induced anticancer activities are due to silencing of TXNDC5 and IDH-1. RD and Rh30 cells were transfected with siTXNDC5 (A) or siIDH-1(B) in the presence or absence of siIL-24 and whole cell lysates were analyzed by western blots. RD and Rh30 cells were treated as described in (A)/(B) in the presence or absence of co-transfected siIL-24 and the effects on cell proliferation (C), Annexin V staining (D), and cell migration (E) were determined as outlined in the Materials and Methods, (F) Model describing the anticancer activities of NR4A1 antagonists. Results are expressed as means ± SD for at three replicate determinations for each treatment group (C, D+E) and significant (p<0.05) effects (*) and reversal of these responses (**) are indicated.