Skip to main content
. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Cancer Immunol Res. 2019 Aug 28;7(11):1837–1848. doi: 10.1158/2326-6066.CIR-19-0229

Figure 4. Activation of STING pathway in human melanoma cell lines improves cytotoxic T lymphocyte-mediated lysis.

Figure 4.

51Cr cytotoxicity assay using (A) WM39 (B) MART-1 pulsed WM39, (C) WM39 plus W6/32, (D) WM3629, and (E) 526-MEL cells as target cells and TIL 195 as effector cells at the indicated effector/target (E/T) ratios with or without 2’3’-cGAMP. Data represent the mean ± SD of quadruplicate wells (representative of three independent experiments). (F) Lytic activity of TIL 195 against different agonist-treated and untreated melanoma targets was measured in lytic units (106 divided by the number of effector cells required to cause 20% lysis of 5 × 103 tumor cells). Data shown are representative of three independent experiments.