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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Mol Cancer Ther. 2019 Sep 5;18(11):1916–1925. doi: 10.1158/1535-7163.MCT-18-1334

Figure 6: Gene set enrichment analysis (GSEA) according to FDR value in RX-5902 sensitive vs. resistant cell lines.

Figure 6:

(A) GSEA was performed using baseline gene expression profiling in 14 sensitive cell lines (IC50 ≤100 nM) and 4 resistant cell lines (IC50 >100 nM) from Figure 1. Hallmark gene sets enriched in sensitive cell lines vs. resistance cell lines (FDR < 0.05). Hallmark gene sets enriched in the sensitive and resistant cell lines are highlighted in red and blue color, respectively. Selected enrichment plots for sensitive cell lines: (B) EMT, (C) TGF beta, (D) WNT/ β -catenin signaling pathway, and (E) inflammatory response. Selected enrichment plots for resistant cell lines: (F) MYC target V2 and (G) MYC target V1.