Table 3. Key genes associated with prognosis of cholangiocarcinoma patients in hub modules.

Gene	Full name	Module	HR	95% CI	P-value
SOX2	SRY-box 2	tan	0.382	[0.145–1.002]	0.043
KIT	KIT proto-oncogene receptor tyrosine kinase	tan	0.341	[0.132–0.883]	0.048
PRSS56	Serine protease 56	tan	2.876	[1.048–7.892]	0.018
WNT9A	Wnt family member 9A	tan	0.389	[0.144–1.050]	0.041
SLC4A4	Solute carrier family 4 member 4	tan	0.352	[0.133–0.931]	0.025
PRRG4	Proline rich and Gla domain 4	tan	0.339	[0.127–0.900]	0.023
PANX2	Pannexin 2	tan	2.600	[0.963–7.022]	0.037
PIR	Pirin	tan	2.701	[0.994–7.337]	0.027
RASSF8	Ras association domain family member 8	tan	0.396	[0.147–1.065]	0.040
MFSD4A	Major facilitator superfamily domain containing 4A	salmon	0.371	[0.143–0.962]	0.043
INS	Insulin	salmon	4.670	[0.458–47.564]	0.006
RNF39	Ring finger protein 39	salmon	2.811	[1.063–7.434]	0.032
IL1R2	Interleukin 1 receptor type 2	salmon	0.379	[0.144–0.997]	0.041
CST1	Cystatin SN	salmon	2.846	[1.039–7.797]	0.017
PPP3CA	Protein phosphatase 3 catalytic subunit alpha	salmon	3.151	[1.129–8.793]	0.010