Table 3.

Main Characteristics of the Include Studies for Clinical Studies

Study	Region	Tumor type	Sample size	Test method	Cut off	Outcome measure	HR estimation	Follow up Months
Ge 2013	China	CRC	189	qRT-PCR	ROC	OS	Directly	~90
Yan 2015	China	HCC	117	qRT-PCR	Median value	OS	Directly	~60
Shi 2015	China	ESCC	194	qRT-PCR	Median value	OS	Directly	~60
Qin 2016	China	ESCC	321	PCR, Sequencing	Median value	OS	Directly	~60
Cui 2017	China	GC	175	qRT-PCR	Median value	OS	Directly	~60

CRC, Colorectal cancer; HCC, Hepatocellular carcinoma; ESCC, Esophageal squamous cell carcinoma; GC, Gastric cancer; OS, overall survival; ROC, Receiver Operating Characteristic