Table 3.
Replication of Metabolites Associated With Physical Activity Among 2,305 Participants in the Women’s Health Initiative, 1993
| Metabolite | HMDB ID | Multivariable Modela | Multivariable Model Further Adjusting for BMIb | ||
|---|---|---|---|---|---|
| β (SE) (×10−3) | P Value | β (SE) (×10−3) | P Value | ||
| Cholesteryl esters | |||||
| C18:2 CE | HMDB00610 | 2.52 (1.73) | 0.15 | 1.64 (1.74) | 0.35 |
| C18:1 CE | HMDB00918 | 5.46 (1.72) | 0.002 | 5.02 (1.74) | 0.004 |
| C16:0 CE | HMDB00885 | 4.11 (1.71) | 0.02 | 3.82 (1.73) | 0.03 |
| C18:3 CE | HMDB10370 | 3.00 (1.71) | 0.08 | 3.23 (1.72) | 0.06 |
| C22:4 CE | HMDB06729 | 4.24 (1.68) | 0.01 | 2.55 (1.67) | 0.13 |
| Phospholipids | |||||
| C18:2 LPC | HMDB10386 | 7.41 (1.70) | <0.001 | 5.14 (1.68) | 0.002 |
| C20:5 LPC | HMDB10397 | 6.86 (1.67) | <0.001 | 5.49 (1.66) | 0.001 |
| C18:1 LPC | HMDB02815 | 6.46 (1.71) | <0.001 | 4.56 (1.69) | 0.01 |
| C36:4 PC-A | HMDB07983 | 3.55 (1.70) | 0.04 | 2.45 (1.70) | 0.15 |
| C34:3 PC plasmalogen | HMDB11211 | 7.74 (1.70) | <0.001 | 5.77 (1.68) | <0.001 |
| C36:3 PC plasmalogen | HMDB11244 | 3.22 (1.73) | 0.06 | 1.86 (1.73) | 0.28 |
| C36:2 PC plasmalogen | HMDB11243 | 3.21 (1.72) | 0.06 | 1.48 (1.71) | 0.39 |
| C34:2 PC plasmalogen | HMDB11210 | 3.82 (1.74) | 0.03 | 2.52 (1.74) | 0.15 |
| C36:2 PC | HMDB08039 | 1.16 (1.71) | 0.50 | 0.89 (1.72) | 0.61 |
| C36:0 PC | HMDB08036 | 4.48 (1.74) | 0.01 | 3.40 (1.74) | 0.05 |
| C18:2 LPE | HMDB11507 | 3.14 (1.66) | 0.06 | 2.20 (1.67) | 0.19 |
| C18:1 LPE | HMDB11506 | 2.89 (1.71) | 0.09 | 1.96 (1.72) | 0.25 |
| C38:3 PE plasmalogen | HMDB11384 | 5.30 (1.74) | 0.002 | 3.96 (1.74) | 0.02 |
| C40:6 PE | HMDB09012 | −1.18 (1.68) | 0.48 | −0.35 (1.69) | 0.84 |
| C38:2 PE | HMDB08942 | 4.23 (1.68) | 0.01 | 2.38 (1.66) | 0.15 |
| C34:0 PIc | HMDB09805 | ||||
| Glycerolipids | |||||
| C34:3 DG | HMDB07132 | −4.95 (1.65) | 0.003 | −3.15 (1.64) | 0.05 |
| C34:2 DG | HMDB07103 | −5.68 (1.68) | <0.001 | −3.42 (1.65) | 0.04 |
| C32:1 DG | HMDB07099 | −4.77 (1.67) | 0.004 | −2.57 (1.64) | 0.12 |
| C34:1 DG | HMDB07102 | −5.81 (1.70) | <0.001 | −3.24 (1.66) | 0.05 |
| C32:0 DG | HMDB07098 | −6.00 (1.70) | <0.001 | −3.46 (1.66) | 0.04 |
| C50:2 TG | HMDB05377 | −5.77 (1.67) | <0.001 | −3.29 (1.64) | 0.04 |
| C52:2 TG | HMDB05369 | −5.72 (1.69) | <0.001 | −3.26 (1.65) | 0.05 |
| C50:3 TG | HMDB05433 | −4.14 (1.65) | 0.01 | −2.26 (1.64) | 0.17 |
| C50:1 TG | HMDB05360 | −5.96 (1.70) | <0.001 | −3.16 (1.65) | 0.06 |
| Sphingolipids | |||||
| C22:1 SM | HMDB12104 | 3.57 (1.73) | 0.04 | 3.38 (1.74) | 0.05 |
| C18 carnitine | HMDB00848 | 0.25 (1.66) | 0.88 | −0.27 (1.67) | 0.87 |
| Amino acids | |||||
| Glycine | HMDB00123 | 8.23 (1.71) | <0.001 | 6.02 (1.68) | <0.001 |
| Citrulline | HMDB00904 | 2.76 (1.69) | 0.10 | 1.54 (1.69) | 0.36 |
| Glutamate | HMDB00148 | −4.14 (1.68) | 0.01 | −2.86 (1.68) | 0.09 |
| Asparagine | HMDB00168 | 6.40 (1.64) | <0.001 | 4.10 (1.61) | 0.01 |
| Others | |||||
| 1-Methyladenosine | HMDB03331 | −5.10 (1.72) | 0.003 | −3.44 (1.71) | 0.04 |
| Creatine | HMDB00064 | −2.04 (1.74) | 0.24 | −1.79 (1.75) | 0.31 |
Abbreviations: BMI, body mass index; CE, cholesteryl ester; DG, diglyceride; HMDB, Human Metabolome Database; ID, identification number; LPC, lysophosphatidylcholines; LPE, lysophosphatidylethanolamine; PC, phosphocholine; PC-A, phosphocholine subtype A; PE, phosphatidylethanolamine; PI, phosphatidylinositol; SE, standard error; SM, sphingomyelin; TG, triglyceride.
a Multivariable model adjusting for age (years; continuous), coronary heart disease case-control status (case, control), Women’s Health Initiative substudy (Observational Study, Estrogen-Alone Trial, or Estrogen Plus Progestin Trial), smoking status (never, past, or current smoker), fasting status (yes, no), alcohol intake (g/day; continuous), Alternative Healthy Eating Index score (0–100; continuous), total energy intake (kcal/day; continuous), and racial/ethnic group (white, black, Hispanic, Asian, or other).
b BMI is calculated as weight (kg)/height (m)2.
c No data were available for this metabolite in the Women’s Health Initiative.