Table 2.

Clinical Features of the ZTTK syndrome reported in literatures to date

Conditions	percentage	Literatures
Developmental delay/Intellectual disability	100%	Zhu et al. (2015), Takenouchi et al. (2016), Kim et al. (2016), Tokita et al. (2016)
Brain malformation	85%	Zhu et al. (2015), Kim et al. (2016), Tokita et al. (2016)
Ventricular enlargement	50%	Kim et al. (2016)
Corpus callosum abnormality	43%	Kim et al. (2016), Tokita et al. (2016)
Cortex malformation	25%	Kim et al. (2016)
White matter abnormalities	18%	Zhu et al. (2015), Kim et al. (2016)
Cerebellar abnormalities	14%	Kim et al. (2016)
Other	18%	Kim et al. (2016), Tokita et al. (2016)
Neurological features	66%	Zhu et al. (2015), Takenouchi et al. (2016), Kim et al. (2016), Tokita et al. (2016)
Seizures	50%	Zhu et al. (2015), Kim et al. (2016), Tokita et al. (2016)
Hypotonia	75%	Takenouchi et al. (2016), Kim et al. (2016),, Tokita et al. (2016)
Musculoskeletal abnormalities	79%	Kim et al. (2016), Tokita et al. (2016)
Hypermobility	28%	Kim et al. (2016)
Scoliosis or kyphosis	14%	Kim et al. (2016)
Hemivertebrae	7%	Kim et al. (2016)
Contractures	7%	Kim et al. (2016)
Other	83%	Kim et al. (2016), Tokita et al. (2016)
Eye and/or vision abnormality	71%	Kim et al. (2016), Tokita et al. (2016)
Strabismus	54%	Kim et al. (2016), Tokita et al. (2016)
Suspicion of cortical visual impairment	18%	Kim et al. (2016), Tokita et al. (2016)
Hypermetropia	21%	Kim et al. (2016)
Heart defect	30%	Zhu et al. (2015), Takenouchi et al. (2016), Kim et al. (2016), Tokita et al. (2016)
Gastrointestinal malformation	39%	Zhu et al. (2015), Kim et al. (2016)
Urogenital malformation	37%	Kim et al. (2016), Tokita et al. (2016)
Facial dysmorphism	100%	Takenouchi et al. (2016), Kim et al. (2016), Tokita et al. (2016)
Short stature	52%	Takenouchi et al. (2016), Kim et al. (2016), Tokita et al. (2016)
Craniosynostosis	10%	Kim et al. (2016)