Table 4.

GO analysis of targets of the downregulated DEMs

Category	ID	Description	Count	p value
Biological process	GO:0050789	Regulation of biological process	1751	3.20E‐14
	GO:0032502	Developmental process	971	2.54E‐12
	GO:0065007	Biological regulation	1823	4.59E‐12
	GO:0008152	Metabolic process	1739	1.54E‐09
	GO:0009987	Cellular process	2,326	2.36E‐08
Molecular function	GO:0003700	Transcription factor activity, sequence‐specific DNA binding	211	2.91E‐10
	GO:0005515	Protein binding	1,418	1.46E‐09
	GO:0003677	DNA binding	329	2.10E‐09
	GO:0046872	Metal ion binding	371	5.25E‐06
	GO:0,004,674	Protein serine/threonine kinase activity	87	9.51E‐06
Cellular component	GO:0005654	Nucleoplasm	513	2.50E‐10
	GO:0005634	Nucleus	912	2.98E‐09
	GO:0005737	Cytoplasm	861	6.78E‐07
	GO:0030054	Cell junction	102	6.97E‐06
	GO:0045202	Synapse	47	6.87E‐05

Abbreviations: DEMs, differentially expressed microRNAs; GO, gene ontology.