Table 4.

Genotype distribution among pediatric patients with hemophilia according to clinical variables

Clinical variables	MTHFR 677 genotypes			p‐value
	CC	CT	TT
Number of affected joints (n = 47), mean ± SD (n)	0.55 ± 0.7 (n = 11)	1.33 ± 0.9 (n = 30)	1.83 ± 0.9 (n = 6)	.015a .023b

	Denver/European scale	MTHFR 1298 genotypes
		AA	AC
Effusion (n = 18), mean ± SD (n)	Radiologist 1	0.38 ± 0.52 (n = 8)	0.90 ± 0.31 (n = 10)	.043c
	Radiologist 2	0.50 ± 0.53 (n = 8)	1.20 ± 0.63 (n = 10)	.036c

		TNFα−308 genotypes
		GG	GA
Number of subchondral cysts (n = 18), mean ± SD (n)	Radiologist 1	0.07 ± 0.26 (n = 14)	0.75 ± 0.95 (n = 4)	.041c
Hemarthrosis (n = 18), mean ± SD (n)	Radiologist 2	0.21 ± 0.42 (n = 14)	0.75 ± 0.50 (n = 4)	.051c

^aANOVA.

^bBonferroni (CC vs. TT).

^cMann–Whitney.