Table 2.

Hazard ratios (95% confidence intervals) of incident ischemic cardiovascular disease (coronary heart disease or ischemic stroke) by quartiles or SD increment of high molecular weight kininogen or prekallikrein, ARIC, 1993–95 through 2016.

	Quartiles
	Q1	Q2	Q3	Q4	Per SDa increment
High molecular weight kininogen, μg/mL	2.08–19.25	19.26–22.81	22.82–26.98	26.98–58.57
n at risk	889	890	890	889
Incident CVD, n	145	156	170	147
Model 1 HR (95% CI)	1 (Reference)	1.14 (0.91–1.43)	1.30 (1.04–1.63)	1.15 (0.91–1.45)	1.04 (0.97–1.13)
Model 2 HR (95% CI)	1 (Reference)	1.15 (0.91–1.44)	1.21 (0.96–1.51)	0.99 (0.78–1.25)	0.99 (0.91–1.08)
Prekallikrein, μg/mL	2.07–10.78	10.79–12.96	12.97–15.90	15.90–95.79
n at risk	889	890	890	889
Incident CVD, n	178	151	143	146
Model 1 HR (95% CI)	1 (Reference)	0.91 (0.73–1.13)	0.94 (0.75–1.17)	1.05 (0.83–1.32)	1.02 (0.94–1.11)
Model 2 HR (95% CI)	1 (Reference)	0.90 (0.72–1.12)	0.88 (0.70–1.10)	0.96 (0.76–1.22)	1.02 (0.94–1.11)

Model 1: Adjusted for age, race, and sex.

Model 2: Adjusted for age, race, sex-hormone replacement therapy, body mass index, diabetes, smoking and drinking status, systolic blood pressure, antihypertensive medications, estimated glomerular filtration rate, total cholesterol, high density lipoprotein cholesterol, and previous history of atrial fibrillation.

ARIC, Atherosclerosis Risk in Communities; CI, confidence interval; CVD, cardiovascular disease; HR, hazard ratio; SD, standard deviation.

^aSD denotes standard deviation, which for high molecular weight kininogen was 6.4 μg/ml and for prekallikrein was 9.2 μg/ml.