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Kaplan‐Meier analysis of time to treatment failure, CNS‐PFS, and overall survival in the entire population (a, b, and c). Kaplan‐Meier analysis of time to treatment failure, CNS‐PFS, and overall survival compared between patients treated with upfront brain radiotherapy (RT) and those treated without upfront RT (d, e, and f). CI, confidence interval; CNS, central nervous system; PFS, progression‐free survival. 
1st RT and 
1st TKI.
