Figure 5.

Pedigree chart and glucokinase (GCK) genetic analysis of case 2. (a) Pedigree chart shows that the mutations in this pedigree were likely inherited in an autosomal dominant pattern. The maternal grandfather (I.1) had died without genetic analysis or glucose detection. The proband's mother (II.2) and an aunt (II.3) were also found to have asymptomatic fasting hypoglycemia. The maternal grandmother (I.2) was still alive with no GCK mutation detected. (b) GCK genetic analysis of case 2 (I.1) and her living relatives: genetic analysis shows a novel heterozygous mutation in GCK coding region in case 2, her mother (II.2) and an aunt (II.3): c.269 A>G p.K90R.