Table 2:
Test | Phenotype tested | Phenotype present in Chat-Mecp2-/y mice ? |
---|---|---|
General health exam | Weight | NS from no transgene; Mecp2 flox |
General health exam | Stereotypies | No |
Elevated plus maze | Anxiety-like behavior | No |
Light/dark box | Anxiety-like behavior | No |
Open field arena | Anxiety-like behavior | No |
Open field arena | Hypo/hyperactivity | No |
Rotarod | Motor learning | NS from no transgene; Mecp2 flox |
Rotarod | Motor coordination | NS from no transgene; Mecp2 flox |
Grip strength meter | Motor strength | No |
Prepulse inhibition | Sensory gating | No |
Passive avoidance | Contextual learning | No |
Aging of animal | Reduced survival | Yes |