Table 2.
Cox regression analysis adjusted for ACh, Stage, and Charlson comorbidity index (CCI)
| Recurrence | Death | |||
|---|---|---|---|---|
| HR | aHRa | HR | aHRa | |
| Group | ||||
| Prevalent | Ref. | — | Ref. | — |
| Incident | 1.4 (0.9‐2.4) | — | 1.4 (0.9‐2.3) | — |
| Interval | 3.3 (2.0‐5.3) | — | 3.5 (2.1‐5.7) | — |
| Group + Ach | ||||
| Prevalent, no chemotherapy | Ref. | Ref. | Ref. | Ref. |
| Prevalent, with chemotherapy | 2.4 (0.9‐6.0) | 1,2 (0,4‐3,4) | 1.9 (0.7‐4.6) | 1,2 (0,4‐3,3) |
| Incident, with chemotherapy | 3.1 (1.4‐7.0) | 1,4 (0,6‐3,6) | 2.5 (1.1‐5.4) | 1,5 (0,6‐3,6) |
| Incident no chemotherapy | 1.9 (0.8‐4.3) | 1,4 (0,6‐3,6) | 1.7 (0.8‐3.7) | 1,4 (0,6‐3,2) |
| Interval, with chemotherapy | 5.0 (2.3‐11.2) | 1,9 (0,8‐4,9) | 4.5 (2.1‐9.7) | 2,1 (0,9‐5,1) |
| Interval, no chemotherapy | 6.4 (2.9‐14.6) | 2,2 (0,9‐5,7) | 6.1 (2.8‐13.3) | 2,5 (1,0 −6,2) |
| Age | ||||
| 1.01 (0.98‐1.04) | — | 1.02 (0.99‐1.05) | — | |
| Comorbidity | ||||
| Absent | Ref. | — | Ref. | — |
| Present | 1.1 (0.78‐1.56) | — | 1.43 (1.03‐1.99) | — |
| CCI | ||||
| 1.0 (0.93‐1.13) | 1.1 (0.9‐1.2) | 1.1 (1.01‐1.20) | 1.1 (1‐1.2) | |
| Phenotype | ||||
| Luminal A | Ref. | Ref. | Ref. | Ref. |
| Luminal B | 1.2 (0.8‐1.9) | 1.0 (0.6‐1.6) | ||
| Her2 | 3.2 (1.9‐5.3) | 2.8 (1.7‐4.6) | ||
| Triple negative | 2.2 (1.3‐3.7) | 2.0 (1.2‐3.4) | ||
| Stage | ||||
| I | Ref. | Ref. | Ref. | Ref. |
| IN SITU | 0.3 (0.1‐1.0) | 0,2 (0,1‐1) | 0.2 (0.0‐0.8) | 0,2 (0,1‐0,9) |
| II | 1.4 (1.0‐2.2) | 1,1 (0,7‐1,8) | 1.2 (0.8‐1.8) | 0,9 (0,6‐1,5) |
| III | 5.5 (3.7‐8.1) | 4,3 (2,7‐6,9) | 4.3 (2.9‐6.4) | 3,1 (2,0‐4,9) |
| IV | — | — | ||
| Oestrogen receptors | ||||
| Negative | Ref. | — | Ref. | — |
| Positive | 0.6 (0.4‐0.8) | — | 0.5 (0.4‐0.8) | — |
| Progesterone receptors | ||||
| Negative | Ref. | — | Ref. | — |
| Positive | 0.6 (0.4‐0.8) | — | 0.6 (0.4‐0.8) | — |
| Her 2 | ||||
| Negative | Ref. | — | Ref. | — |
| Positive | 1.7 (1.2‐2.5) | — | 1.6 (1.1‐2.3) | — |
| Ki67 expression | ||||
| ≤14% | Ref. | — | Ref. | — |
| >14% | 1.9 (1.2‐3.0) | — | 1.9 (1.2‐3.1) | — |
| Grade | ||||
| I | Ref. | — | Ref. | — |
| II | 2.1 (1.2‐3.7) | — | 1.9 (1.1‐3.1) | — |
| III | 3.1 (1.8‐5.4) | — | 2.5 (1.5‐4.1) | — |
| Other | 0.7 (0.2‐2.4) | — | 0.6 (0.2‐1.9) | — |
Sample evaluated: recurrence n = 1.028, Sample evaluated: death n = 1.024.
a
Cox regression analysis adjusted for ACh, Stage, and Charlson comorbidity Index.