Table 2.
Reported treatment‐emerged adverse events
| Total N = 38 | Number (%) | ||
|---|---|---|---|
| Original imatinib |
Generic imatinib Persistent symptoms |
Generic imatinib New or worsening symptoms |
|
| Non hematologic AE (any grade) | |||
| Muscle cramps | 22 (58) | 11 (29) | 8 (21) |
| Edema | 21 (55) | 7 (18) | 5 (13) |
| Diarrhea | 14 (37) | 0 (0) | 6 (16) |
| Fatigue | 13 (34) | 5 (13) | 5 (13) |
| Nausea | 11 (29) | 4 (11) | 7 (18) |
| Increased creatinine | 5 (13) | 2 (5) | 4 (11) |
| Rash | 4 (11) | 0 (0) | 1 (3) |
| Weight gain | 3 (8) | 0 (0) | 0 (0) |
| Increased LDH | 3 (8) | 2 (5) | 1 (3) |
| Increased Bilirubin | 1 (3) | 0 (0) | 0 (0) |
| Increased ALT | 1 (3) | 1 (3) | 0 (0) |
| Insomnia | 1 (3) | 0 (0) | 2 (5) |
| Pruritus | 1 (3) | 0 (0) | 0 (0) |
| Hematologic AE (any grade) | |||
| Anemia | 13 (34) | 6 (16) | 2 (5) |
| Thrombocytopenia | 3 (8) | 1 (3) | 0 (0) |
| Neutropenia | 1 (3) | 0 (0) | 2 (5) |