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Cardiac regeneration in zebrafish. Following cardiac injury, diploid cardiomyocytes undergo dedifferentiation and proliferate to replace the damaged tissue. Signals from the activated epicardium and endocardium, such as retinoic acid (RA) and vascular endothelial growth factor Aa (Vegfaa), stimulate such proliferation, whilst epicardial fibroblast growth factor (FGF) signalling induces neovascularisation to restore blood flow.
