Figure 1.

Experimental design. Starting at 2.5 months of age, female APP/PS1 and NonTg mice (APP/PS1 CTL = 10, NonTg CTL = 7, APP/PS1 Ch+ = 10, NonTg Ch+ = 7) were assigned to receive one of two concentrations of choline in diet; a diet containing 1.1 g/kg of choline (CTL) or a choline supplemented diet containing 5.0 g/kg of choline (Ch+). All mice were aged to 10 months and behaviorally tested in the hippocampal dependent Morris water maze task. Mice were subsequently sacrificed, and their brains were prepared for neuropathological assays