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. 2019 Sep 27;18(6):e13037. doi: 10.1111/acel.13037

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© 2019 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Lifelong choline supplementation reduces activated microglia. (a) Photomicrographs depicting the Cornus Ammonis 1 (CA1) of the hippocampus from APP/PS1 and NonTg mice fluorescently stained for CD68 and Iba1. Images taken at 10X; Scale bar = 150 µm (n = 6 mice/group). Arrows illustrate colocalization of CD68/Iba1. (b) Quantitative analysis reveals a significant main effect of genotype, where the APP/PS1 mice have a significantly higher intensity of yellow pixels of CD68/Iba1 colocalization than the NonTg mice (p < .05). Additionally, we find a significant main effect of diet, where the Ch+ groups show a significant reduction in CD68/Iba1 colocalization than the CTL groups (p < .001). Data are presented as box plots. The center line represents the median value, the limits represent the 25th and 75th percentile, and the whiskers represent the minimum and maximum value of the distribution. *p < .05, ***p < .001