Table 4.

SNP‐protein associations and their replication in two independent sets

				NECS			Science (Serum)		Nature (Plasma)
	SomaID	Uniprot	geneID	beta	SE	p	beta	p	beta	SE	p
rs7412/ T	10046‐55	Q13490	BIRC2	1.21	0.07	2.41E−38	1.70	1.39E−302
	11276‐1	Q86XR8	CEP57	0.21	0.02	4.07E−15	0.90	7.42E−70
	5918‐5	Q06323	PSME1	0.26	0.03	1.14E−13	0.66	1.63E−41	1.06	0.04	4.30E−137
	14318‐1	Q9UBQ0	VPS29	0.17	0.03	2.10E−09	1.25	1.51E−147	1.69	0.04	0
	2418‐55	P02649	APOE	−0.23	0.05	2.67E−06	−0.80	2.73E−56
	11402‐17	Q8NEZ4	KMT2C	0.11	0.03	5.19E−05	0.38	1.23E−13	.59	0.05	6.90E−39
	9207‐60	O95825	CRYZL1	−0.17	0.04	8.70E−05	−0.71	9.61E−47
	14643‐27	O60870	KIN	0.09	0.02	.00014	0.50	1.67E−23
	7223‐60	Q99584	S100A13	−0.19	0.05	.00017	−0.83	1.85E−62
	6378‐2	Q86SI9	C5orf38	−0.18	0.05	.00109	−1.02	1.64E−92
	5345‐51	Q8WWK9	CKAP2	0.12	0.04	.00171	0.43	7.53E−18
	12500‐88	Q9UBT2	UBA2	0.10	0.04	.01052	1.47	3.74E−210
	2797‐56	P04114	APOB	−0.12	0.07	.06623	−0.57	9.23E−30
rs429358/T	11293‐14	Q6UXK5	LRRN1	−0.26	0.04	8.01E−10			−1.18	0.03	0
	13732‐79	Q16619	CTF1	−0.15	0.02	5.56E−09			−.80	0.03	3.50E−148
	12501‐10	O75347	TBCA	0.16	0.03	2.54E−08			1.34	0.02	0

NECS: beta coefficients and standard errors estimated from linear regression of log‐transformed protein data, adjusted for age and sex.

Science (Serum): beta coefficients estimated from linear regression of Yeo–Johnson transformation of protein data (Emilsson et al., 2018). Cis‐ and trans‐effects available only for rs7412.

Nature (Plasma): beta coefficients and standard errors estimated from fixed‐effect inverse‐variance meta‐analysis of two cohorts (Sun et al., 2018). Cohorts specific results reported beta coefficients of SNPs on log‐transformed protein levels, adjusted for sex, age, BMI, and additional covariates.

Data of missing proteins were not available.