Figure 2.

Sleep and wake genes identified in the young and old mice. The Venn diagrams show the number of common sleep or wake genes identified in both young and old mice, and age‐specific genes. A total of 982 sleep genes and 1,075 wake genes are common between the age‐groups. A total of 876 sleep and 869 wake genes are found only in young mice (Y‐specific), while 272 sleep and 203 wake genes are found only in old mice (O‐specific). Percentages of expression changes relative to baseline (ZT0) of each gene during SS or SD were calculated and trend lines were plotted using Loess local regression (with 95% CI) for common, young‐specific or old‐specific genes over time. Both common and young‐specific genes showed a reduction in the magnitude of change between SS and ZT0 in the old mice compared to the young. Y.SS = young mice during SS; Y.SD = young mice during SD; O.SS = old mice during SS; O.SD = old mice during SD