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. 2019 Sep 24;18(6):e13021. doi: 10.1111/acel.13021

Table 1.

Enriched functions among sleep and wake genes from young and/or old mice

Gene list Function clusters ESa N termsb N genesc Example genes
Enriched functions among sleep genes
Common

  • DNA repair

 2.05 9 41 Exo1, Brca2, Rad50, Pole, Casp3

  • Signal/transmembrane

 1.77 5 322 Gabra4, Grin3a, Clcc1, Slc13a5

  • G‐protein‐coupled receptor

 1.77 3 29 Gpr12, Gpr21, Gpr25, Gpr165
Young‐specific

  • Cell adhesion

 3.98 4 75 Cdh7, Pcdh10, Reln, Nrxn3

  • Axon guidance

 2.33 5 32 Met, Mapk1, Ppp3ca, Ppp3cb

  • Signal/transmembrane

 2.22 5 287 Abca1, Gpr22, Slitrk2, Slc22a3

  • Kinase activity

 1.63 3 4 Cmpk1, Cmpk2, Ak8, Nme5

  • Chloride channel activity

 1.44 4 9 Gabrb2, Gabrg2, Clcn3, Slc26a4
Old‐specific

  • Collagen/glycoprotein

 2.70 6 85 Cdhr3, Col14a1, Col5a1, Mmp11

  • Transmembrane

 2.43 5 115 Cdhr3, Cacna2d4, Slc24a4, Slc9a3

  • Calcium transport

 1.74 7 30 Cdhr3, Cacna2d4, Mmp11, Slc9a3
Enriched functions among wake genes
Common

  • ER stress

 2.77 10 57 Hspb1, Hspa5, Dnajb5, Pdia4, Xbp1
 

  • Regulation of transcription

 2.50 20 415 Egr1, Fos, Fosb, Junb, Crem

  • Response to VEGF

 2.34 3 10 Vegfa, Egr3, Srf, Xbp1

  • Dephosphorylation

 2.28 8 23 Dusp1, Dusp4, Dusp5, Ptpn1

  • Rhythmic process

 2.17 7 34 Arntl, Per1, Per2, Crem, Sik1

  • FoxO signaling

 2.16 4 34 Cdkn1a, Ccnb1, CCnd3

  • Response to cAMP

 2.15 4 32 Crem, Sik1, Fos, Egr1

  • MAPK signaling

 2.14 13 92 Fos, Hspb1, Cdkn1a

  • Kinase activity

 2.12 10 149 Sik1, Cdkn1a, Ccnb1

  • Cytokine activity

 1.75 6 34 Crh, Scg2, Il12a, Cx3cl1

  • Dioxygenase activity

 1.74 4 18 Scd4, P4ha1, Ptgs2, Tet3

  • Fat cell differentiation

 1.70 3 15 Egr2, Nr4a1, Nr4a2, Nr4a3
Young‐specific

  • Actin binding

 2.15 4 42 Crocc, Tns1, Fscn1, Fhod1

  • GTPase activation

 1.52 3 26 Arhgef19, Arhgap4, Arhgef1
Old‐specific

  • Lipid transport

 1.92 4 9 Star, Plekha3, Plekha8, Snx16

  • Regulation of transcription

 1.58 3 70 Atf3, Ppargc1b, Zfp568

  • Negative regulation of T‐cell receptor signaling pathway

 1.50 4 5 Ptpn22, Dusp3, Dusp7, Ephx2
a

Enrichment score (equivalent to –log10‐transformed geometric mean of the p‐values of the included terms)

b

Number of functional terms in each functional cluster

c

Number of unique genes included in each functional cluster.