Figure 5.

Genetic inactivation of p38α in neurons delays cognitive decline (a) T‐maze correct choice rate of aged (over 16‐month‐old) wt and p38α∆‐N mice (n = 11) with 10‐ and 40‐s retention. (b) Average speed (cm/s) in peripheral zone in wt and p38α∆‐N mice (n ≥ 10) in the open‐field test and (c) individual and average distance (m) performed by wt and p38α∆‐N mice (n ≥ 10) in the open‐field test. (d) Grip strength values obtained in middle age (10‐ to 15‐month‐old) and aged > 15 months wt (n = 8 and n = 5, respectively) and p38α∆‐N (n = 9 and n = 8) mice. (e) Body weight of (over 12‐month‐old) wt and p38α∆‐N mice (n = 17). (f) Quantification of head‐dipping in aged (over 16‐month‐old) wt (n = 11) and p38α∆‐N (n = 6) mice. (g) Percentage of aged wt (n = 14) and p38α∆‐N (n = 10) mice that successfully passed the tightrope test. Fisher's exact test for each age group is relative to wt