. 2019 Jul-Sep;11(3):31–37. doi: 10.32607/20758251-2019-11-3-31-37

Table 1.

Neuroprotective and neuroregenerative effects of GK-2 (1 mg/kg, 7 days) in a model of ischemic stroke caused by transient occlusion of the middle cerebral artery in rats

First administration after surgery, h	Reduction in the ischemic injury volume [17], %	Stimulation of neurogenesis (based on the Ki67 proliferation marker), therapeutic effect,%		Stimulation of synaptogenesis in the striatum (based on the postsynaptic marker PSD-95), therapeutic effect, %
First administration after surgery, h	Reduction in the ischemic injury volume [17], %	hippocampus	striatum
6	60^*	220^*	37^{^}	72^*
24	24^*	205^*	36^{^}	30^{^}

Note:The therapeutic effect was calculated using the formula: [(protein level in the stroke + GK-2 group – protein level in the stroke group)/(protein level in the sham-surgery group – protein level in the stroke group)] × 100% * – p < 0.05; ^ – p < 0.1 compared to the stroke group (Mann–Whitney U-test).