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. 2019 Oct 30;12:8895–8904. doi: 10.2147/OTT.S222608

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© 2019 Huang et al.

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TIMP1 is identified to be consistently upregulated in the initiation and progression of ucaCRC. (A) Target genes of mesalazine obtained from the Drug Repurposing Hub. (B) The Module obtained from the PPI network constructed from 7 target genes of mesalazine and the overlapped 78 DEGs between GSE9452 and GSE8671. (C) Relative expression of 8 hub genes after mesalazine treatment in UC (GSE46451) and CRC (GSE14538), respectively. (D) Diagram of the process of AOM/DSS-induced colitis-associated mice CRC model. (E) Relative expression of TIMP1 in the process of AOM/DSS-induced colitis-associated mice CRC model based on GSE31106 dataset.