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. 2019 Sep 24;42(6):2255–2266. doi: 10.3892/or.2019.7332

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Copyright: © Dai et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 9. — Interactions between ANLN and KDR as validated using SUM149PT and MCF10A cells. (A) Expression of KDR on modulating the expression of ANLN and the expression of ANLN after modulating KDR in SUM149PT breast cancer cells. (B) Expression of KDR after modulating the expression of ANLN and the expression of ANLN after modulating KDR in MCF10A normal breast epithelial cells. Bars represent the mean ± SD from at least three independent experiments (*0.01<P<0.05 and **P<0.01 by ANOVA and Scheffe's post hoc test). Gene expression in each experimental group was normalized by the corresponding control. ANLN-up, dCas9-SAM and sgRNA upregulating ANLN were co-transfected into SUM149PT or MCF10A cells; ANLN-down, dCas9-KRAB and sgRNA downregulating ANLN co-transfected into cells; KDR-up, dCas9-SAM and sgRNA upregulating KDR co-transfected into cells; KDR-down, dCas9-KRAB and sgRNA downregulating KDR co-transfected into cells; Control, sgRNAs up- and downregulating ANLN and KDR co-transfected into cells; ANLN, anillin actin-binding protein; KDR, kinase insert domain receptor.