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. 2019 Oct 1;42(6):2355–2362. doi: 10.3892/or.2019.7350

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Copyright: © Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Drug resistance in parental rat glioma cells (C6 cells) induced promotion of cell invasion. (A) Transwell assays were carried out for TMZ-resistant rat glioma cells (C6-PL3) and C6 cells. Images of cells stained with Giemsa invading through Matrigel in a representative experiment are presented, and results of 15 different regions in three independent experiments (five regions per experiment) are summarized in (B) with an ×200 magnification. (C-H) Rats were allografted with C6-PL3 and C6 cells for 20 days. Brain slices were collected and stained. Representative images of brain slices collected from different rats are presented, with arrows indicating C6 glioma cells. Dotted lines indicate the boundary between tumor and normal brain tissue. (I) Quantitative results from both groups (three rats/group) are summarized. **P<0.01 and ***P<0.001. TMZ, temozolomide.