Figure 7.

CCL5 activated NF-κB signaling pathway through recruitment of TAM to promote tumor migration and invasion. (A) Expression changes of MMP9 before and after co-culture of MCF-7 cells with TAMs. *P<0.05. (B) Expression of NF-κB before and after co-culture MCF-7 cells with TAMs. *P<0.05. (C) EMT markers and MMP9 in MCF-7/siNC cells co-cultured with TAM after PDTC treatment. MMP9, matrix metalloprotease 9; NF-κB, nuclear factor-κB; PDTC, pyrrolidinedithiocarbamate; siCCL5, small interfering RNA C-C motif chemokine ligand 5; siNC, small interfering RNA negative control; TAMs, associated macrophages.