Table 4.
Genotype frequencies of tested single nucleotide polymorphisms (SNPs) in the COPD cases and the control population and their associations with COPD adjusted for age, gender and smoking status.
| Adjusted for Age/Gender/Smoking | |||||
|---|---|---|---|---|---|
| SNP | Genotype | COPD Cases | Controls | OR (95%CI 2) 1 | p |
| rs12150220 | A/A | 113 (29.20%) | 307 (24.64%) | 1.00 | |
| A/T | 190 (49.10%) | 642 (51.52%) | 0.54 (0.31–0.95) | 0.03 * | |
| T/T | 84 (21.71%) | 297 (23.84%) | 0.59 (0.28–1.26) | 0.17 | |
| A/T+T/T | 274 (70.80%) | 939 (75.36%) | 0.55 (0.32–0.95) | 0.03 * | |
| rs35596958 | T/T | 335 (86.79%) | 1086 (87.16%) | 1.00 | |
| C/T | 49 (12.69%) | 160 (12.84%) | 0.86 (0.42–1.78) | 0.69 | |
| C/C | 2 (0.52%) | 0 (0.00%) | - | - | |
| rs1043673 | C/C | 152 (39.79%) | 471 (37.83%) | 1.00 | |
| A/C | 177 (46.34%) | 589 (47.31%) | 1.13 (0.65–1.95) | 0.67 | |
| A/A | 53 (13.87%) | 185 (14.86%) | 0.92 (0.42–2.01) | 0.83 | |
| rs35829419 | C/C | 346 (89.41%) | 1141 (91.35%) | 1.00 | |
| A/C | 39 (10.08%) | 107 (8.57%) | 1.07 (0.44–2.58) | 0.88 | |
| A/A | 2 (0.52%) | 1 (0.08%) | - | 0.80 | |
| rs441827 | C/C | 155 (40.16%) | 464 (37.09%) | 1.00 | |
| T/C | 168 (43.52%) | 598 (47.80%) | 0.82 (0.47–1.44) | 0.49 | |
| T/T | 63 (16.32%) | 189 (15.11%) | 1.02 (0.50–2.10) | 0.95 | |
| rs12462372 | G/G | 354 (91.00%) | 1092 (88.21%) | 1.00 | |
| A/G | 34 (8.74%) | 143 (11.55%) | 0.36 (0.15–0.90) | 0.03 * | |
| A/A | 1 (0.26%) | 3 (0.24%) | 0.29 (0.00–949.77) | 0.77 | |
| A/G+A/A | 35 (9.00%) | 146 (11.79%) | 0.36 (0.15–0.90) | 0.03 * | |
| rs17857373 | G/G | 359 (92.76%) | 1162 (92.89%) | 1.00 | |
| C/G | 26 (6.72%) | 88 (7.03%) | 0.96 (0.34–2.69) | 0.94 | |
| C/C | 2 (0.52%) | 1 (0.08%) | - | - | |
| rs302453 | A/A | 215 (55.41%) | 681 (54.83%) | 1.00 | |
| A/T | 159 (40.98%) | 471 (37.92%) | 1.59 (0.94–2.71) | 0.09 | |
| T/T | 14 (3.61%) | 90 (7.25%) | 0.31 (0.09–0.99) | 0.05 | |
| rs10409555 | G/G | 212 (54.78%) | 664 (53.12%) | 1.00 | |
| A/G | 142 (36.69%) | 495 (39.60%) | 0.59 (0.34–1.03) | 0.06 | |
| A/A | 33 (8.53%) | 91 (7.28%) | 1.75 (0.73–4.20) | 0.21 | |
| rs16986899 | T/T | 268 (69.79%) | 857 (68.89%) | 1.00 | |
| C/T | 104 (27.08%) | 348 (27.97%) | 1.17 (0.66–2.07) | 0.60 | |
| C/C | 12 (3.13%) | 39 (3.14%) | 0.77 (0.19–3.06) | 0.71 | |
| rs471979 | G/G | 293 (79.62%) | 962 (80.37%) | 1.00 | |
| C/G | 68 (18.48%) | 219 (18.30%) | 0.72 (0.36–1.43) | 0.35 | |
| C/C | 7 (1.90%) | 16 (1.34%) | 4.14 (0.93–18.49) | 0.06 | |
| rs56159585 | T/T | 320 (82.69%) | 969 (79.23%) | 1.00 | |
| A/T | 61 (15.76%) | 238 (19.46%) | 0.54 (0.27–1.07) | 0.08 | |
| A/A | 6 (1.55%) | 16 (1.31%) | 0.11 (0.00–4.43) | 0.24 | |
| rs77447196 | C/C | 265 (68.48%) | 823 (66.42%) | 1.00 | |
| C/G | 117 (30.23%) | 363 (29.30%) | 0.72 (0.40–1.29) | 0.27 | |
| G/G | 5 (1.29%) | 53 (4.28%) | 0.38 (0.07–2.12) | 0.27 | |
| rs306457 | C/C | 227 (58.81%) | 757 (60.71%) | 1.00 | |
| C/G | 134 (34.72%) | 413 (33.12%) | 1.08 (0.63–1.85) | 0.77 | |
| G/G | 25 (6.48%) | 77 (6.17%) | 0.39 (0.12–1.30) | 0.12 | |
| rs306481 | G/G | 142 (36.50%) | 405 (32.58%) | 1.00 | |
| A/G | 190 (48.84%) | 604 (48.59%) | 0.95 (0.55–1.65) | 0.86 | |
| A/A | 57 (14.65%) | 234 (18.83%) | 0.60 (0.27–1.33) | 0.21 | |
| rs12461110 | G/G | 158 (41.15%) | 501 (40.14%) | 1.00 | |
| A/G | 160 (41.67%) | 568 (45.51%) | 0.76 (0.44–1.33) | 0.34 | |
| A/A | 66 (17.19%) | 179 (14.34%) | 1.26 (0.61–2.61) | 0.54 | |
| rs299163 | A/A | 349 (89.95%) | 1066 (85.76%) | 1.00 | |
| A/C | 38 (9.79%) | 172 (13.84%) | 0.93 (0.46–1.90) | 0.85 | |
| C/C | 1 (0.26%) | 5 (0.40%) | 0.02 (0.00–11710.48) | 0.57 | |
| rs34436714 | C/C | 251 (65.88%) | 771 (61.98%) | 1.00 | |
| A/C | 117 (30.71%) | 407 (32.72%) | 0.62 (0.35–1.08) | 0.09 | |
| A/A | 13 (3.41%) | 66 (5.31%) | 0.40 (0.11–1.43) | 0.16 | |
| rs34971363 | G/G | 325 (83.98%) | 1049 (83.79%) | 1.00 | |
| C/G | 60 (15.50%) | 191 (15.26%) | 1.26 (0.62–2.58) | 0.52 | |
| C/C | 2 (0.52%) | 12 (0.96%) | 0.41 (0.01–31.83) | 0.69 | |
| rs303997 | C/C | 124 (32.12%) | 418 (33.63%) | 1.00 | |
| C/T | 201 (52.07%) | 630 (50.68%) | 1.13 (0.65–1.98) | 0.67 | |
| T/T | 61 (15.80%) | 195 (15.69%) | 1.09 (0.51–2.30) | 0.83 | |
* p values <0.05 1 OR, odds ratio 2 CI, confidence interval.