Table 1.
Clinicopathological characteristics of NSCLC patients related to irisin expression in cancer cells and stoma cells.
| Clinicopathological Parameter | n 729 (%) |
Irisin Expression in NSCLC Cancer Cells | Irisin Expression in NSCLC Stromal Cells | ||||
|---|---|---|---|---|---|---|---|
| Low 1–4 |
High 5–12 |
Chi2Test p Value |
Low 1–4 |
High 5–12 |
Chi2Test p Value |
||
| Age ≤60 | 290 (39.8) | 248 (85.5) | 42 (14.5) | 0.3911 | 155 (53.4) | 135 (46.6) | 0.7797 |
| > 60 | 439 (60.2) | 365 (83.1) | 74 (16.9) | 230 (52.4) | 209 (47.6) | ||
| Sex Male | 540 (74) | 458 (84.8) | 82 (15.2) | 0.3644 | 275 (50.8) | 265 (49.2) | 0.0846 |
| Female | 189 (26) | 155 (82) | 34 (18) | 110 (58.2) | 79 (41.8) | ||
| Smoking Status Yes | 631 (86.5) | 535 (84.8) | 96 (15.2) | 0.1909 | 325 (51.5) | 306 (48.5) | 0.0475 |
| No | 98 (13.5) | 78 (79.6) | 20 (20.4) | 61 (62.2) | 37 (37.8) | ||
| Histology Type AC | 348 (47.6) | 273 (78.5) | 75 (21.5) | <0.0001 | 221 (63.5) | 127 (36.5) | <0.0001 |
| SCC | 381 (52.4) | 340 (89.2) | 41 (10.8) | 164 (43) | 217 (57) | ||
| Tumour Size (T) T1 | 177 (24.3) | 148 (83.5) | 29 (16.4) | <0.0001 | 102 (57.5) | 75 (42.5) | 0.3027 |
| T2 | 329 (45.1) | 272 (82.8) | 57 (17.2) | 166 (50.4) | 163 (49.6) | ||
| T3–4 | 223 (30.6) | 120 (53.7) | 103 (46.3) | 117 (52.5) | 106 (47.5) | ||
| Lymph Nodes (N) N0 | 474 (65) | 400 (84.4) | 74 (15.6) | 0.0076 | 252 (53.2) | 222 (46.8) | 0.3235 |
| N1 | 134 (18.4) | 121 (90.3) | 13 (9.7) | 64 (47.8) | 70 (52.2) | ||
| N2 | 121 (16.6) | 92 (76) | 29 (24) | 69 (57.2) | 52 (42.8) | ||
| Metastasis (M) M0 | 723 (99.2) | 608 (84.1) | 115 (15.9) | 0.9595 | 723 | 0 | <0.0001 |
| M1b | 6 (0.8) | 5 (83.3) | 1 (16.7) | 0 | 6 | ||
| Stage I | 267 (36.6) | 113 (42.3) | 154 (57.7) | <0.0001 | 150 (56.2) | 117 (43.8) | 0.1049 |
| II | 245 (33.6) | 213 (86.9) | 32 (13.1) | 116 (47.3) | 129 (52.7) | ||
| III–IV | 217 (29.8) | 176 (81.1) | 41 (18.9) | 119 (54.8) | 98 (45.2) | ||
| Grade of malignancy (G) G1 | 47 (6.4) | 34 (72.5) | 13 (27.5) | 0.0607 | 28 (59.6) | 19 (40.4) | 0.0183 |
| G2 | 548 (75.2) | 456 (83.2) | 92 (16.8) | 270 (49.3) | 278 (50.7) | ||
| G3 | 134 (18.4) | 117 (87.3) | 12 (12.7) | 83 (61.9) | 51 (38.1) | ||
NSCLC—non-small cell lung cancer; AC—adenocarcinoma, SCC—squamous cell carcinoma; significance in bold.