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. 2019 Oct 1;8(10):434. doi: 10.3390/antiox8100434

Figure 1.

Figure 1

H2O2 levels and survival of primary hepatocytes. Data are expressed as means ± SD. Statistical significance is represented by “*” symbols ***: P < 0.001. (a) H2O2 generation in primary hepatocytes significantly differs among all measured time points (P = 1 × 10−15, Kruskal-Wallis rank sum test; day 0 to day 3: P < 10−18; day 0 to day 6: P = 6 × 10−16; day 3 to day 6: 4 × 10−5; Dunnett T3 post hoc test). (b) Reduced H2O2 generation in the presence (+) of N-acetylcysteine (NAC) (P = 6 × 10−18, Kruskal–Wallis rank sum test). (c) Survival of the primary hepatocytes in culture measured as total protein concentrations and expressed as percentage of the protein concentration of the cells attached after isolation (P = 0.004, one-way ANOVA). Statistical significance between the cells at time point 0 and 3 days and 0 and 6 days (P = 0.039 and P = 0.004, respectively, Bonferroni post hoc test).