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. 2019 Sep 28;11(10):1456. doi: 10.3390/cancers11101456

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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IPA reduces CRC growth in vivo. (A) Tumor volume growth curve of DLD1-xenograft (left panel, n = 20 mice, 10 mice in each group) and HCT116-xenograft (right panel; n = 20 mice, 10 mice in each group) after peri-tumoral injection of IPA. Growth retardation by the compound was statistically significant for all time points labelled with * (one-way ANOVA p < 0.05), with # (one-way ANOVA p < 0.01) and § (one-way ANOVA p < 0.001). Western blot and densitometry analysis of FBXW7, RNF20 (B), phosphorylated-c-Myc (Thr58) and Mcl1 (C) in whole lysate from representative resected tumor tissues. GAPDH was used as loading control. Data are expressed as mean ± SD of at least four independent experiments. * p < 0.05, *** p < 0.005 vs. control group.