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. 2019 Oct 18;11(10):1590. doi: 10.3390/cancers11101590

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of EP4 antagonists AH23848 and RQ15986 on SK-UT-1 and SK-UT-1B on proliferation and response to docetaxel (A,B) There was a modest effect on cell proliferation on SK-UT-1 (7% decrease, n.s.) and SK-UT-1B (20% decrease, n.s.). Data are normalized to the vehicle control. Error bars represent experiments performed in triplicate. (C) Sarcoma cell line SK-UT-1 (IC₅₀ 1.5 nM) was more chemoresistant to docetaxel than carcinoma cell line SK-UT-1B (IC₅₀ 0.5 nM). (D,E) Pre-treatment with EP4 antagonist (either AH23848 or RQ15986) increased chemosensitivity to docetaxel in both cell lines by approximately 2-fold. Statistics: one-way ANOVA with post hoc analysis. Combination drug treatment compared to docetaxel. AH: AH23848. RQ: RQ15986. ** p < 0.01, *** p < 0.001.