Figure 1.

The design, synthesis, and functional characterization of the novel multi-target small molecule dopamine antagonist, LCC-09. Schema showing (A) several novel series of 5-(2′,4′-difluorophenyl)-salicylanilide derivatives based on difluorobiphenyl and salicylanilide scaffolds, and (B) the pharmacological rationale for the synthesis of LCC-09, consisting of 2,4-difluorophenyl and paeonol moiety of salicylate. (C) Pie-chart showing computer-assisted predicted targets of LCC-09 and the target class frequency (left panel), and a list of predicted LCC-09-targeted dopamine receptors DRD1, DRD2, DRD3, and DRD4 (right panel). (D) A schema of LCC-09-relevant therapeutic targets of glioblastoma (GBM).