Figure 5.

Representative snapshots of the persistent interaction modes between CHE and G4 in hybrid, parallel, and antiparallel conformations from different sequences (see Methods): (a) “edge”/parallel; (b) “in”/parallel; (c) “edge”/hybrid; (d) “in”/hybrid; (e) “edge”/antiparallel. (f) Schematic representation of the competitive “in” and “edge” interaction modes. The ellipsoids represent π-stacked nucleobases in the G4 core. Note that for antiparallel G4, only one stable interaction mode has been obtained.