Table 1.

Experimental binding constants (K_b) and binding free energies (ΔG) for the CHE–DNA complexes. The calculated ΔG values are also shown for comparison.

DNA	Experimental Kb (M−1)	Experimental ΔG (kcal/mol)	Calculated ΔG (kcal/mol)
B-DNA	(1.3 ± 0.2) × 104	−5.6 ± 0.1
Hybrid G4 (2Y9A)	(1.1 ± 0.1) × 105	−6.9 ± 0.1	−12.3
Parallel G4 (c-MYC)	(1.0 ± 0.1) × 105	−6.8 ± 0.02	−13.5
Antiparallel G4 (hTelo)	(2.69 ± 0.06) × 105	−7.4 ± 0.2
Parallel G4 (hTelo + PEG)	(3.5 ± 0.9) × 105	−7.6 ± 0.1