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. 2019 Oct 4;10(10):777. doi: 10.3390/genes10100777

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The inferred regulatory network of the anthocyanin biosynthetic pathway in the chrysanthemum. CmMYB4 and CmMYB5 negatively (marked by green with dashed line) regulate the expression of structural genes CmCHS, CmF3H, CmDFR, and CmANS, and correspondingly suppress the biosynthesis and accumulation of anthocyanins in the chrysanthemum capitulum. On the contrary, the expressions of CmCHS, CmCHI, CmF3H, CmDFR, and CmANS are positively regulated by CmMYB6 and CmMYB7 (marked by red with full line) and therefore promote the biosynthesis and accumulation of anthocyanins.