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Potential mechanisms underlying the C3G-Ms regulated Nrf2 system. PCA and FA may induce the nuclear translocation of Nrf2 via JNK and PI3K/Akt pathways, respectively. FA, ferulic acid; GPx, glutathione peroxidase; GR, glutathione reductase; JNK, c-Jun NH2-terminal kinase; KEAP1, Kelch like-ECH-associated protein 1; Nrf2, nuclear factor (erythroid-derived 2)-like 2; PCA, protocatechuic acid; PI3K, phosphatidylinositol 3-Kinase.
